Adipocyte Differentiation: When precursors are also regulators
نویسندگان
چکیده
As well as being the precursors of the triacylglycerols deposited as fat in adipose tissue, long-chain fatty acids are one class of agents that induce the differentiation of preadipocytes to adipocytes.
منابع مشابه
Decrease in transforming growth factor beta 1 binding during differentiation of rat adipocyte precursors in primary culture.
Transforming growth factor beta 1 (TGF-beta 1) binding and action were investigated during differentiation of adipocyte precursors freshly isolated from rat inguinal fat-pad cultivated in defined medium. The data presented in this paper indicate that TGF-beta 1 inhibits differentiation of adipocyte precursors with a 50% effective dose of 9 pM. Time course experiments demonstrate that TGF-beta 1...
متن کاملAdipocyte Precursors: Developmental Origins, Self-Renewal, and Plasticity
M.E. Symonds (ed.), Adipose Tissue Biology, DOI 10.1007/978-1-4614-0965-6_1, © Springer Science+Business Media, LLC 2012 Abstract The current epidemic of obesity and overweight has caused a surge of interest in the study of adipose tissue formation. Much progress has been made in defi ning the transcriptional networks controlling the terminal differentiation of preadipocytes into mature adipocy...
متن کاملIdentification of Regulatory Elements That Control PPARγ Expression in Adipocyte Progenitors
Adipose tissue renewal and obesity-driven expansion of fat cell number are dependent on proliferation and differentiation of adipose progenitors that reside in the vasculature that develops in coordination with adipose depots. The transcriptional events that regulate commitment of progenitors to the adipose lineage are poorly understood. Because expression of the nuclear receptor PPARγ defines ...
متن کامل[Cloning and characterization of inducible genes at the beginning of adipocyte differentiation].
Adipocyte differentiation takes place via a complex series of steps. While PPAR gamma and C/EBP alpha are known to be master regulators, the events at the earliest stage of adipocyte differentiation are not yet known. In this study, we cloned the genes that are induced at the beginning of the differentiation of 3T3-L1 preadipocyte cells. Of 102 clones obtained, only several clones were already ...
متن کاملDietary and species influence on potential of plasma to stimulate differentiation and lipid accumulation in cultured adipocyte precursors.
Sera and plasma from different species and from rats of various dietary statuses were compared with regard to effects on proliferation, glycerophosphate dehydrogenase (GPDH) activity, and lipid-filing of rat adipocyte precursors converting to adipocytes in primary cell culture. All of the tested sera and plasma samples were comparably supportive of cell multiplication, but their effects on elev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 5 شماره
صفحات -
تاریخ انتشار 1995